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Friday, December 8, 2023

Most cancers immunotheranostics utilizing bioactive nanocoated photosynthetic bacterial complexes

Creating new modalities that permit multidimensional remedy with optical and immunological rules is a problem forward of pharmacology and drug discovery for efficient most cancers remedy. To this finish, superior purple photosynthetic micro organism, which present distinctive near-infrared (NIR) fluorescence, robust photothermal conversion skill, and excessive biocompatibility, have been screened from varied bacterial strains. To enhance the therapeutic performances of screened micro organism, we additional designed and developed easy chemical bacterial membrane functionalization with bioactive molecules and polyethylene glycol derivatives. Exploring the physicochemical and physiological properties of the chemically functionalized micro organism complexes achieved wonderful tumor focusing on and powerful anticancer efficacies. The extremely biocompatible purposeful micro organism confirmed cytotoxic immunological results, robust NIR fluorescence, and highly effective photothermal conversion within the focused tumor milieu below biologically penetrating NIR gentle irradiation.

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